Figure 4. Selective loss of Kcnq2 from the nodes of sensory axons.

These are digital images of unfixed mouse teased nerves, double-labeled for either Kv7.2 or Kv7.3 (red) and panNav (green). In the dorsal roots of mutant animals (columns A and B), Kv7.2 is not detected at any node (arrowheads), whereas Kv7.3 is found at every node (arrows). In the ventral roots of mutant mice (columns C and D), note that all nodes are Kv7.2- and Kv7.3-positive (arrows). Scale bar: 10 μm.