Figure 6. NK4 is more effective than PHA-665752 in suppression of mesothelioma.
(A) Cells were untreated, treated with PHA-665752 (1 μmol/L), or infected with Ad-NK4. Both PHA-665752 and NK4 inhibited phosphorylation of Met and suppressed active form of β-catenin. (B) NK4 was more effective than PHA-665752 in suppression of mesothelioma spheroid formation. Bars shown represent mean ± s.d. PHA-665752 versus Ad-LacZ (*, p < 0.05); Ad-NK4 versus PHA-665752 (**, p < 0.05).