Table 3.
Serum TNFa and Adipokines in women with PCOS
| PCOS | ||||||
|---|---|---|---|---|---|---|
| Pre-Exercise | Exercise Duration | p value | ||||
| Week 4 | Week 8 | Week 12 | Week 16 | |||
| WBC (× 103/μL) | 8.7 ± 1.4 | 8.1 ± 1.6 | 8.2 ± 1.4 | 7.6 ± 1.4b | 7.5 ± 1.1b | 0.02 |
| Neutrophils (× 103/μL) | 4.2 ± 1.2 | 4.2 ± 1.3 | 4.8 ± 1.4 | 4.1 ± 1.4 | 4.1 ± 1 | 0.13 |
| hsCRP (mg/L) | 4.6 ± 6.1 | 4.5 ± 4.9 | 3.5 ± 2.8 | 4.4 ± 5.2 | 4.7 ± 4.5 | 0.47 |
| Triglycerides (mg/dL) | 95 ± 49.8 | 77.3 ± 49.4 | 71.7 ± 34.3 | 84.3 ± 44.8 | 76.6 ± 37.4c | 0.16 |
| Total Cholesterol (mg/dL) | 165.5 ± 40.7 | 174 ± 35.7 | 174.7 ± 35.6 | 169.1 ± 36 | 179.8 ± 38.1c | 0.25 |
| HDL-C (mg/dL) | 50.6 ± 11.7 | 57.9 ± 11.3b | 58.8 ± 14.1b | 57.9 ± 13.4b | 59.3 ± 11.4b | < 0.001 |
| LDL-C (mg/dL) | 95.9 ± 24.1 | 100.5 ± 21.8 | 101.6 ± 19.8 | 94.3 ± 23.7 | 105.2 ± 24.7c | 0.20 |
| Cholesterol/HDL | 3.3 ± 0.4 | 3.0 ± 0.5 | 3.0 ± 0.4a | 2.9 ± 0.6b | 3.0 ± 0.4c | 0.07 |
| HDL/LDL | 0.5 ± 0.1 | 0.5 ± 0.1 | 0.5 ± 0.1 | 0.6 ± 0.1b | 0.5 ± 0.1 | 0.05 |
| DHEA-S (μg/dL) | 183.2 ± 80.3 | 232.3 ± 132.4b | 226.2 ± 129.5b | 226.5 ± 120.3b | 219 ± 87.7c | 0.09 |
| Total Adiponectin (μg/mL) | 2.7 ± 1.3 | 2.5 ± 0.6 | 2.6 ± 0.8 | 2.6 ± 1.2 | 2.4 ± 1 | 0.95 |
| TNFa (pg/mL) | 12.8 ± 3.3 | 12.5 ± 4.6 | 10.6 ± 4.4c | 12.1 ± 3.1c | 13.1 ± 4.7 | 0.55 |
| Leptin (μg/mL) | 33.1 ± 11.7 | 24.7 ± 13.6b | 25.5 ± 13.8a | 24.6 ± 13.3b | 26.1 ± 13.9 | 0.07 |
| HMW-Adiponectin (ng/mL) | 28.2 ± 24.4 | 32.2 ± 23.8 | 45.8 ± 47.9 | 38 ± 37 | 33 ± 19.7 | 0.30 |
| Leptin/Total Adiponectin | 10.5 ± 2.4 | 9.3 ± 5.5 | 9.2 ± 6.3 | 9.3 ± 6.7 | 9.6 ± 5.1 | 0.97 |
| Leptin/HMW-Adiponectin | 2.6 ± 2.2 | 0.7 ± 0.3 | 1 ± 1.1 | 0.9 ± 0.8b | 0.7 ± 0.3b | 0.03 |
Data is represented as mean ± SD. The p values presented in the table were obtained from repeated measures one-way ANOVAs. Trends and significance indicated from Dunnett's multiple comparisons tests:
a
p < 0.10 vs Pre-Exercise PCOS
b
p < 0.05 vs Pre-Exercise PCOS.
Significance indicated from paired t-tests:
c
p < 0.05 vs Pre-Exercise PCOS.
WBC, White Blood Cell Count; hsCRP, high sensitivity C-Reactive Protein; HDL-C, High Density Lipoprotein-Cholesterol; LDL-C, Low Density Lipoprotein-Cholesterol; DHEA-S, Dehydroepiandrosterone-Sulfate; TNFa, Tumor Necrotizing Factor alpha; HMW, High Molecular Weight.