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. 2015 May 12;10(5):e0126801. doi: 10.1371/journal.pone.0126801

Fig 1. Delayed initiation of germinal vesicle breakdown (GVBD) and meiotic maturation in the oocytes treated with forskolin (FSK) and 3-isobutyl-1-methylxanthine (IBMX).

Fig 1

A) The GVBD rate at 0, 0.5, 1, 2, 4, 8, and 12 h in IVM culture. Delayed GVBD was observed in the FSK and IBMX groups. B) The maturation rate at 22, 26, and 30 h after the initiation of IVM culture. Although delay in oocyte maturation occurred in the FSK and IBMX groups, the maturation rates at 30 h were comparable to those in the control groups. Error bars represent standard error of the mean. Bars labeled with different letters show significant differences (P < 0.05).