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Schematic of role of hypermethylated genes and acetylated histones in the progression from normal mucosa to esophageal adenocarcinoma. Chronic inflammation due to gastroesophageal reflux disease is understood to be the primary factor that drives this pathogenesis. The figure offers a potential role for hypermethylated genes and altered histones in this progression.23, 75, 76, 77, 78
