Table 3. Drug-induced hepatotoxicity.
| Random week | Hepatotoxicity | TB therapy interrupted due to hepatotoxicity. Total no, (%) | TB therapy interrupted due to hepatotoxicity (mortality cases, no(%) | Days TB therapy was interrupted due to hepatotoxicity, median (range) | |
|---|---|---|---|---|---|
| Grade 1 & 2 | Grade 3 & 4 | ||||
| Week one (n = 163) | 88(54%) | 27(16%) | 22(12.3%) | 11/27 (40.7%) | 14(4–30) |
| Week four (n = 160) | 104(65%) | 23(14.4%) | 13(8.1%) | 4/20(20%) | 15(9–30) |
| Week eight (n = 155) | 86(55.5%) | 21(13.5%) | 14(9%) | 1/17(5.9%) | 14(8–30) |
| Total (n = 478) | 278(58.2%) | 71(14.9%) | 49(10.3%) | 16/64 (25%) | 14(4–30) |