Table 3. Multivariate Cox Model with delayed entry for first onset of incident GAD (n=1367, 97 cases)a.
| Characteristic | HR | 95% CI | P |
|---|---|---|---|
| Female gender | 3.43 | 1.83–6.41 | 0.0001 |
| Waist-to-hip ratio (WHR ⩾0.94) | 1.89 | 0.93–3.85 | 0.077 |
| LDL-cholesterol (>4.01 mmol l−1) | 0.50 | 0.31–0.82 | 0.006 |
| Arrhythmia and heart failure | 1.91 | 1.15–3.18 | 0.013 |
| Respiratory disorders (dyspnea, asthma or bronchitis) | 2.95 | 1.57–5.55 | 0.0008 |
| Isaacs Set test score (lowest tertile) | 1.61 | 1.03–2.50 | 0.035 |
| Recent adverse events | 1.72 | 1.11–2.68 | 0.016 |
| Current major depression | 3.60 | 1.69–7.67 | 0.0009 |
| Current phobia | 2.55 | 1.51–4.30 | 0.0005 |
Abbreviations: CI, confidence interval; GAD, generalized anxiety disorder; HR, hazard ratio; LDL, low-density lipoprotein.
a
Multivariate models included baseline covariates meeting Martingale residual criteria for proportionality of risk and associated with first onset of incident GAD in Cox models adjusted for age and sex (P<0.15) and were reduced using a backward selection procedure keeping in the final model all the covariates significant at P<0.15. Psychotropic medications initially included were not retained in the final model (P=0.23).