Table 1.
Demographic and Clinical Variables by Treatment Group
| Characteristic | Donepezil Group (n = 99) |
Control Group (n = 99) |
||
|---|---|---|---|---|
| No. | % | No. | % | |
| Age, years | ||||
| Median | 56 | 54 | ||
| Range | 19 to 84 | 19 to 81 | ||
| ≥ 50 | 58 | 59 | 61 | 62 |
| Months since diagnosis | ||||
| Median | 37.7 | 39.9 | ||
| Range | 7.3 to 298.4 | 8.8 to 423.2 | ||
| ≥ 36 | 51 | 52 | 55 | 56 |
| BMI, kg/m2 | ||||
| Median | 27.2 | 27.9 | ||
| Range | 17.3 to 49.4 | 18.4 to 41.1 | ||
| < 25 (underweight to normal) | 36 | 36 | 28 | 28 |
| 25 to 30 (overweight) | 31 | 31 | 36 | 36 |
| ≥ 30 (obese) | 32 | 32 | 35 | 35 |
| Strata | ||||
| WBI, WFU | 10 | 10 | 10 | 10 |
| WBI, CCOP | 30 | 30 | 30 | 30 |
| PBI, WFU | 30 | 30 | 30 | 30 |
| PBI, CCOP | 29 | 29 | 29 | 29 |
| ECOG performance status | ||||
| 0 | 49 | 49 | 45 | 45 |
| 1 | 46 | 46 | 48 | 48 |
| 2 | 4 | 4 | 6 | 6 |
| Sex | ||||
| Female | 56 | 57 | 50 | 51 |
| Male | 43 | 43 | 49 | 49 |
| Race | ||||
| Hispanic | 1 | 1 | 0 | 0 |
| Asian | 1 | 1 | 0 | 0 |
| Black | 7 | 7 | 9 | 9 |
| White | 90 | 91 | 90 | 91 |
| Marital status* | ||||
| Single | 12 | 12 | 10 | 10 |
| Married or married-like | 66 | 67 | 73 | 74 |
| Separated, divorced, or widowed | 21 | 21 | 15 | 15 |
| Education* | ||||
| ≤ High school | 29 | 29 | 33 | 34 |
| Vocational or some college | 39 | 39 | 40 | 42 |
| ≥ College graduate | 31 | 31 | 23 | 24 |
| Income, US$* | ||||
| < 20,000 | 31 | 36 | 34 | 42 |
| 20,000 to 50,000 | 31 | 36 | 27 | 33 |
| ≥ 50,000 | 24 | 28 | 20 | 25 |
| Work outside home* | 28 | 28 | 31 | 32 |
| Diagnosis | ||||
| Primary brain tumor | 65 | 66 | 65 | 66 |
| Brain metastasis | 27 | 27 | 26 | 26 |
| PCI | 7 | 7 | 8 | 8 |
| Primary tumor type | n = 65 | n = 65 | ||
| Glioblastoma multiforme | 15 | 23 | 8 | 12 |
| Anaplastic astrocytoma | 4 | 6 | 10 | 15 |
| Anaplastic oligodendroglioma | 8 | 12 | 8 | 12 |
| Anaplastic oligoastrocytoma | 2 | 3 | 1 | 2 |
| Anaplastic ependymoma | 3 | 5 | 1 | 2 |
| Anaplastic mixed glioma | 0 | 0 | 1 | 2 |
| Low-grade astrocytoma | 5 | 8 | 1 | 2 |
| Low-grade oligodendroglioma | 5 | 8 | 8 | 12 |
| Low-grade oligoastrocytoma | 0 | 0 | 1 | 2 |
| Meningioma | 13 | 20 | 9 | 14 |
| Pilocycstic astrocytoma | 2 | 3 | 4 | 6 |
| Other | 8 | 12 | 13 | 20 |
| Metastasis site | n = 34 | n = 34 | ||
| Lung | 19 | 57 | 21 | 62 |
| Breast | 9 | 27 | 7 | 21 |
| Other or unknown | 6 | 18 | 6 | 18 |
| Brain volume, cm3* | ||||
| Median | 1,104 | 1,135 | ||
| Range | 865 to 1,421 | 901 to 1,624 | ||
| ≥ 1,200 | 22 | 22 | 30 | 32 |
| CSF volume, cm3* | ||||
| Median | 211 | 204 | ||
| Range | 101 to 376 | 101 to 367 | ||
| ≥ 200 | 54 | 55 | 48 | 51 |
| Brain or intracranial volume, %* | ||||
| Median | 84.0 | 84.5 | ||
| Range | 74.9 to 91.1 | 74.8 to 92.0 | ||
| Lesion or resection volume, cm3* | ||||
| 0 | 9 | 9 | 14 | 15 |
| < 15 | 64 | 65 | 59 | 61 |
| ≥ 15 | 25 | 26 | 23 | 24 |
| Hippocampus involvement* | 13 | 13 | 10 | 10 |
| Location* | ||||
| Frontal | 29 | 32 | 33 | 39 |
| Parietal | 17 | 19 | 11 | 13 |
| Occipital | 6 | 7 | 5 | 6 |
| Temporal | 19 | 21 | 14 | 16 |
| Basal ganglia | 7 | 8 | 8 | 9 |
| Cerebellum | 9 | 10 | 8 | 9 |
| Brainstem or spinal cord | 3 | 3 | 6 | 7 |
Abbreviations: BMI, body mass index; CCOP, community clinical oncology program; ECOG, Eastern Cooperative Oncology Group; PBI, partial-brain irradiation; PCI, —prophylactic cranial irradiation; WBI, whole-brain irradiation; WFU, Wake Forest University.
*
Some missing data.