Table 3.

Pretreatment Raw Means and Post-Treatment (24 weeks) LS Means for Cognitive Function Scores by Treatment Group

Measure	Pretreatment		Post-Treatment
			Donepezil Group			Control Group			Difference	95% CI	P†
	Mean	SD	No.*	LS Mean	SE	No.*	LS Mean	SE
Cognitive composite	0.00	0.73	72	0.22	0.04	72	0.19	0.04	0.03	−0.06 to 0.13	.484
HVLT-R total	20.29	6.42	72	22.48	0.45	73	22.16	0.45	0.32	−0.93 to 1.56	.617
HVLT-R delayed recall	6.23	3.47	72	7.11	0.25	73	6.76	0.25	0.35	−0.36 to 1.06	.334
HVLT-R percent savings	71.16	33.27	72	78.54	3.02	73	74.58	3.02	3.95	−4.48 to 12.39	.356
HVLT-R recognition	10.32	1.86	72	10.91	0.18	73	10.34	0.18	0.57	0.07 to 1.07	.027
HVLT-R discrimination	9.35	2.34	72	10.10	0.24	73	9.16	0.24	0.94	0.26 to 1.62	.007
COWA	29.97	12.96	72	32.27	0.82	73	33.19	0.82	−0.92	−3.21 to 1.37	.428
DST forward	9.56	2.52	72	10.33	0.23	73	10.27	0.22	0.06	−0.56 to 0.68	.851
DST backward	5.46	2.32	72	5.60	0.22	73	6.00	0.22	−0.39	−1.01 to 0.22	.210
DST total	15.02	4.29	72	15.46	0.36	73	15.62	0.35	−0.16	−1.16 to 0.83	.744
mROCF copy	21.07	3.41	72	20.30	0.34	72	20.99	0.34	−0.70	−1.64 to 0.25	.146
mROCF immediate recall	15.55	5.66	72	17.19	0.36	72	17.69	0.36	−0.50	−1.50 to 0.51	.331
mROCF delayed recall	14.65	5.76	72	16.83	0.40	71	17.22	0.40	−0.39	−1.50 to 0.72	.485
TMT-A	50.70	31.32	72	51.38	3.50	73	53.20	3.49	−1.82	−11.57 to 7.92	.713
TMT-B	144.80	88.84	72	136.74	6.30	71	135.13	6.39	1.62	−16.09 to 19.32	.857
GP dominant	117.40	55.10	71	105.06	3.42	70	116.99	3.49	−11.92	−21.58 to −2.27	.016
GP nondominant	131.16	59.08	71	127.25	3.03	71	127.26	3.02	−0.01	−8.45 to 8.42	.997

Abbreviations: COWA, Controlled Oral Word Association Test; DST, Digit Span Test; GP, Grooved Pegboard; HVLT-R, Hopkins Verbal Learning Test–Revised; LS, least squares; mROCF, modified Rey-Osterreith Complex Figure; SD, standard deviation; TMT-A, Trail Making Test Part A; TMT-B, Trail Making Test Part B.

^*No. with 24-week measurements.

^†Unadjusted for multiple comparisons.