Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 23;33(15):1688–1696. doi: 10.1200/JCO.2014.58.0225

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by American Society of Clinical Oncology

PMC Copyright notice

Fig A1. — Characterization of human epidermal growth factor receptor 2 (HER2) chimeric antigen receptor (CAR) T-cell product. (A) HER2-CAR expression on nontransduced (NT) and transduced T cells (NT v HER2-CAR T cells, P < .001). Individual data points and mean are shown. (B) Phenotypic analysis of HER2-CAR T-cell product. CM, central memory (CD3⁺/CD45RO⁺/CD62L⁺); EM, effector memory (CD3⁺/CD45RO⁺/CCR7^–/CD62L^–). Box plot with whiskers (Tukey method) is shown. (C) Cytotoxicity assay using NT and HER2-CAR T cells as effectors and HER2-negative (K562 and MDA-MB-468 [MDA]) or HER2-positive (NCI-H1299 and LM7) cell lines as targets. Mean with standard deviation at an effector-to-target ratio of 20:1 is shown. K562: NT v HER2-CAR T cells, P = not significant (NS); MDA: NT v HER2-CAR T cells, P = NS; NCI-H1229: NT v HER2-CAR T cells, P < .001; LM7: NT v HER2-CAR T cells, P < .001.