Table 2.
Patient No. | Diagnosis | Disease at T-Cell Infusion | T-Cell Dose | Outcome | Overall Survival (days) |
---|---|---|---|---|---|
1 | OS | Right hip, multiple bones | 1 × 104/m2 | PD | 1,109* |
2 | OS | Sacrum | 1 × 104/m2 | NE | 34 |
3 | OS | Right hip, lung | 1 × 104/m2 | PD | 584 |
4 | OS | Lung | 3 × 104/m2 | PD; surgery/salvage chemotherapy for PD; second infusion (1 × 105/m2); PR for 9 months | 874 |
5 | OS | Lung | 3 × 104/m2 | PD; second infusion (1 × 105/m2); PD | 310 |
6 | OS | Lung | 1 × 105/m2 | PD | 107 |
7 | OS | Lung | 1 × 105/m2 | PD; second infusion (1 × 105/m2); PD | 303 |
8 | OS | Pelvis, spine, lung | 1 × 106/m2 | PD | 120 |
9 | OS | Lung | 1 × 106/m2 | PD | 151 |
10 | PNET | Sacrum | 3 × 106/m2 | PD; tumor removed (no necrosis) | 451 |
11 | OS | Lung/pleura | 3 × 106/m2 | SD for 15 weeks; tumor removed (no necrosis); remains in remission | 584* |
12 | DSCRT | Liver | 1 × 107/m2 | 8 additional infusions; SD for 14 months | 528* |
13 | OS | Lung | 1 × 107/m2 | PD | 268 |
14 | OS | Lung/pleura | 3 × 107/m2 | Second infusion; SD for 12 weeks; tumor removed (≥ 90% necrosis); 2 additional infusions; remains in remission | 446* |
15 | OS | Bone, chest wall, brain, spine, marrow | 3 × 107/m2 | PD | 156 |
16 | OS | Pleura, liver, subdiaphragmatic | 1 × 108/m2 | NE | 389* |
17 | ES | Lung | 1 × 108/m2 | PD | 153 |
18 | OS | Left femur | 1 × 108/m2 | Second infusion; SD for 12 weeks; tumor removed (no necrosis); remains in remission | 290* |
19 | OS | Lung and bone | 1 × 108/m2 | PD | 164 |
Abbreviations: DSRCT, desmoplastic small round cell tumor; ES, Ewing sarcoma; NE, not evaluable; OS, osteosarcoma; PD, progressive disease; PR, partial response; PNET, primitive neuroectodermal tumor; SD, stable disease.
Patient still alive.