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. 2015 Mar 23;33(15):1688–1696. doi: 10.1200/JCO.2014.58.0225

Table 2.

Patient Outcome

Patient No. Diagnosis Disease at T-Cell Infusion T-Cell Dose Outcome Overall Survival (days)
1 OS Right hip, multiple bones 1 × 104/m2 PD 1,109*
2 OS Sacrum 1 × 104/m2 NE 34
3 OS Right hip, lung 1 × 104/m2 PD 584
4 OS Lung 3 × 104/m2 PD; surgery/salvage chemotherapy for PD; second infusion (1 × 105/m2); PR for 9 months 874
5 OS Lung 3 × 104/m2 PD; second infusion (1 × 105/m2); PD 310
6 OS Lung 1 × 105/m2 PD 107
7 OS Lung 1 × 105/m2 PD; second infusion (1 × 105/m2); PD 303
8 OS Pelvis, spine, lung 1 × 106/m2 PD 120
9 OS Lung 1 × 106/m2 PD 151
10 PNET Sacrum 3 × 106/m2 PD; tumor removed (no necrosis) 451
11 OS Lung/pleura 3 × 106/m2 SD for 15 weeks; tumor removed (no necrosis); remains in remission 584*
12 DSCRT Liver 1 × 107/m2 8 additional infusions; SD for 14 months 528*
13 OS Lung 1 × 107/m2 PD 268
14 OS Lung/pleura 3 × 107/m2 Second infusion; SD for 12 weeks; tumor removed (≥ 90% necrosis); 2 additional infusions; remains in remission 446*
15 OS Bone, chest wall, brain, spine, marrow 3 × 107/m2 PD 156
16 OS Pleura, liver, subdiaphragmatic 1 × 108/m2 NE 389*
17 ES Lung 1 × 108/m2 PD 153
18 OS Left femur 1 × 108/m2 Second infusion; SD for 12 weeks; tumor removed (no necrosis); remains in remission 290*
19 OS Lung and bone 1 × 108/m2 PD 164

Abbreviations: DSRCT, desmoplastic small round cell tumor; ES, Ewing sarcoma; NE, not evaluable; OS, osteosarcoma; PD, progressive disease; PR, partial response; PNET, primitive neuroectodermal tumor; SD, stable disease.

*

Patient still alive.