Table A2.
Unrelated Reported Adverse Events Within the First 6 Weeks of HER2-CAR T-Cell Infusion
| Adverse Event | Grade 1 |
Grade 2 |
Grade 3 |
Grade 4 |
||||
|---|---|---|---|---|---|---|---|---|
| No. of Patients | % | No. of Patients | % | No. of Patients | % | No. of Patients | % | |
| Hematologic toxicities | ||||||||
| Anemia | 8 | 42.1 | 1 | 5.3 | ||||
| Leukopenia | 5 | 26.3 | 1 | 5.3 | ||||
| Neutropenia | 4 | 21.1 | 1 | 5.3 | ||||
| Lymphopenia | 5 | 26.3 | 1 | 5.3 | ||||
| Nonhematologic toxicities | ||||||||
| General | ||||||||
| Anxiety | 1 | 5.3 | ||||||
| Fatigue | 3 | 15.8 | ||||||
| Fever | 1 | 5.3 | ||||||
| Hot flashes | 2 | 10.5 | ||||||
| Flu-like symptoms | 1 | 5.3 | ||||||
| Muscle weakness | 1 | 5.3 | 1 | 5.3 | ||||
| HEENT | ||||||||
| Watery eye | 1 | 5.3 | ||||||
| Rhinorrhea | 2 | 10.5 | ||||||
| GI | ||||||||
| Dry mouth | 1 | 5.3 | ||||||
| Nausea/vomiting | 5 | 26.3 | 1 | 5.3 | ||||
| Diarrhea | 1 | 5.3 | ||||||
| Constipation | 1 | 5.3 | ||||||
| Cardiac | ||||||||
| Hypotension | 1 | 5.3 | ||||||
| Paroxysmal tachycardia | 1 | 5.3 | ||||||
| Respiratory | ||||||||
| Cough | 5 | 26.3 | ||||||
| Upper respiratory tract infection | 1 | 5.3 | ||||||
| Wheezing | 1 | 5.3 | ||||||
| Pain | ||||||||
| Abdominal | 2 | 10.5 | ||||||
| Back | 2 | 10.5 | 1 | 5.3 | ||||
| Bone | 1 | 5.3 | ||||||
| Chest | 1 | 5.3 | ||||||
| Extremity | 1 | 5.3 | ||||||
| Neck | 1 | 5.3 | ||||||
| Pain NOS | 2 | 10.5 | ||||||
| Throat | 1 | 5.3 | ||||||
| Tumor site | 1 | 5.3 | 1 | 5.3 | ||||
| CNS | ||||||||
| Headache | 2 | 10.5 | ||||||
| Intracranial hemorrhage | 1 | 5.3 | ||||||
| Seizure | 2 | 10.5 | ||||||
| Numbness | 1 | 5.3 | ||||||
| Musculoskeletal | ||||||||
| Bruising | 1 | 5.3 | ||||||
| Ankle fracture | 1 | 5.3 | ||||||
| Laboratory | ||||||||
| ALT | 3 | 15.8 | ||||||
| Alkaline phosphatase | 3 | 15.8 | 2 | 10.5 | ||||
| AST | 6 | 31.6 | ||||||
| Hyperglycemia | 2 | 10.5 | ||||||
| Hyperkalemia | 1 | 5.3 | 1 | 5.3 | ||||
| Hypernatremia | 2 | 10.5 | ||||||
| Hypoalbuminemia | 1 | 5.3 | ||||||
| Hypocalcemia | 2 | 10.5 | ||||||
| Hypokalemia | 5 | 26.3 | ||||||
| Hyponatremia | 3 | 15.8 | ||||||
Abbreviations: CAR, chimeric antigen receptor; HEENT, head, eyes, ears, nose, and throat; HER2, human epidermal growth factor receptor 2; NOS, not otherwise specified.