Table 2.
Effect of SP-A on Lung Metastasis Produced by Lung Adenocarcinoma Cell Lines in Nude Mice
| Cell line | Lung |
Pleural effusion |
|||
|---|---|---|---|---|---|
| Weight (g) | Metastasis |
Incidence | Volume (μL) | ||
| Incidence | No. | ||||
| PC14PE6 | |||||
| Vector | 0.36 (0.30−0.42) | 6/6 | 117.7 (67–183) | 5/6 | 176.7 (0–300) |
| SP-A | 0.27 (0.22−0.31)∗ | 6/6 | 58.8 (21–111)∗ | 0/6 | All 0∗ |
| A549 | |||||
| Vector | 0.48 (0.30−0.85) | 9/9 | All >200 | ||
| SP-A | 0.26 (0.19−0.41)† | 10/10 | All >200 | ||
PC14PE6 or A549 cells (1 × 106 per mouse) were i.v. injected into nude mice, and lung metastasis and pleural effusion were evaluated. Values are means (ranges).
∗
Statistically significant difference compared with PC14PE6/vector (P < 0.05).
†
Statistically significant difference compared with A549/vector (P < 0.05).