Table 3.
Effect of SP-A on Lung Metastasis Produced by PC14PE6 Cells in Nude Mice Depleted of NK Cells
| PC14PE6 | Lung |
Pleural effusion |
|||
|---|---|---|---|---|---|
| Weight (g) | Metastasis |
Incidence | Volume (μL) | ||
| Incidence | No. | ||||
| Vector NK+ | 0.41 (0.24−0.65) | 6/6 | 113.0 (35–197) | 6/6 | 313.3 (20–900) |
| SP-A NK+ | 0.21 (0.15−0.26)∗ | 5/5 | 25.6 (6–34)∗ | 1/5 | 80.0 (0–400) |
| Vector NK– | 0.50 (0.26−0.89) | 7/7 | 148.6 (52–207) | 7/7 | 438.6 (20–1000) |
| SP-A NK– | 0.34 (0.21−0.48) | 5/5 | 101.2 (41–181) | 4/5 | 400.0 (0–1200) |
PC14PE6 cells were i.v. injected into nude mice with or without NK cell depletion, and lung metastasis and pleural effusion were evaluated. Values are means (ranges).
∗
Statistically significant difference compared with vector NK+ (P < 0.05).