Table 1.
Classification of CD subtypes.
| CD subtype | Symptoms | Serology+/HLA++ | Pathology classification | ||
|---|---|---|---|---|---|
| Marsh | Marsh-Oberhuber | Corazza | |||
| Classical | Gastrointestinal symptoms and signs (diarrhea, abdominal distension, constipation, and abdominal pain) | +/+ | Type 2/3* | Type 2/3a, b or c* | Grade A/B1 or B2* |
|
| |||||
| Nonclassical | Extraintestinal symptoms and signs (anemia, neuropathy, osteoporosis, and short stature) | +/+ | Type 2/3 | Type 2/3a, b or c | Grade A/B1 or B2 |
|
| |||||
| Subclinical | Asymptomatic | +/+ | Type 2/3 | Type 2/3a, b or c | Grade A/B1 or B2 |
|
| |||||
| Potential | Presence or absence of symptoms | +/+ | Type 0/1** | Type 0/1** | Normal/Grade A** |
+positive CD-specific serology (mainly IgA-EMA, IgA-tTG, and/or IgG-DGP).
++Presence of genes/haplotype associated with CD (see Table 2).
*Intraepithelial lymphocytosis (≥25/100 enterocytes) with crypt hyperplasia (Marsh-Oberhuber type 2) and partial/total villous atrophy.
**Normal architecture/intraepithelial lymphocytosis.