Table 3.
TXNRD1 SNPs showing at least one significant association with functional parameters under a nominal level (p Model < 0.05), in the sample stratified by age class, as obtained by RobustSNP association test.
| SNP | Sample | Functional parameters | z-score | p Model | theop |
|---|---|---|---|---|---|
| rs4445711 | Long lived | ADL | 2.279 | 0.022 (R) | 0.049 |
| Long lived | Walking | −2.643 | 0.008 (R) | 0.018 | |
|
| |||||
| rs11111979 | Long lived | Walking | −2.341 | 0.019 (R) | 0.042 |
|
| |||||
| rs10861203 | Long lived | HG | 1.985 | 0.047 (D) | 0.099 |
|
| |||||
| rs1128446 | Long lived | Chair stand | −2.296 | 0.021 (R) | 0.046 |
| Younger controls | Chair stand | −2.157 | 0.030 (R) | 0.064 | |
|
| |||||
| rs7310505 | Younger controls | Walking | −2.085 | 0.037 (A) | 0.078 |
z-score represents the z-statistics for the regression analyses; p Model is the p value of the best genetic model, where R is recessive, D is dominant, and A is additive model. theop refers to the p value adjusted for multiple comparisons (due to the three different tested genetic models).