Table 3.
Comparison of edges between cognitively normal individuals and AD-dementia patients for three types of graphs at 9% sparsity.
| Type of edge | Pearson correlation |
Pearson correlation (controlling for mean cortical thickness) |
Partial correlation |
|||
|---|---|---|---|---|---|---|
| Normal | AD | Normal | AD | Normal | AD | |
| Common edges | 58% | 43% | 19% | |||
| Contralateral edges | 47% | 23% | 49% | 33% | 45% | 47% |
| Within lobe & hemisphere | 29% | 35% | 24% | 38% | 19% | 17% |
| Frontal | 58% | 49% | 56% | 54% | 51% | 59% |
| Parietal | 66% | 52% | 58% | 46% | 40% | 39% |
| Temporal | 21% | 35% | 22% | 29% | 45% | 39% |
| Occipital | 5% | 6% | 10% | 12% | 20% | 24% |
| Frontal–parietal | 29% | 17% | 23% | 19% | 10% | 12% |
| Frontal–temporal | 4% | 6% | 7% | 7% | 14% | 17% |
| Frontal–occipital | 0% | 0% | 0% | 1% | 8% | 11% |
| Parietal–temporal | 10% | 12% | 8% | 9% | 15% | 10% |
| Parietal–occipital | 4% | 3% | 6% | 2% | 4% | 7% |
| Temporal–parietal | 0% | 3% | 0% | 3% | 4% | 4% |
Note: Common edges refers to edges that are present in the graphs of both the normal and the AD group; within lobe and hemisphere refers to edges that connect nodes representing brain regions within the same lobe and hemisphere (i.e., local connections); frontal refers to edges that connect a node representing frontal lobe cortex to a node in the same lobe or in another lobe; parietal, temporal, and occipital are defined similarly as frontal; frontal–parietal represent edges that connect a node representing frontal lobe tissue to a node representing parietal lobe tissue.