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. 2015 May 12;5:111. doi: 10.3389/fonc.2015.00111

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Copyright © 2015 Cage, Chanthery, Chesler, Grimmer, Knight, Shokat, Weiss and Gustafson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PW-12 is efficacious in a GEM model of MYCN-amplified neuroblastoma. Tumor-bearing TH-MYCN mice were treated for 14 days with either 25 mg/kg of PW-12 (n = 3) or vehicle alone (n = 3). (A) Western blot for MYCN protein from treated tumors confirm that PW-12 is effective at downregulating MYCN protein production. (B) Tumor size was significantly reduced in treated animals (* represents p < 0.05). (C) Histology for Ki67 and c-Caspase 3 shows increase in apoptosis and decrease in proliferation in treated tumors.