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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Antibiot (Tokyo). 2014 Oct 15;68(4):259–266. doi: 10.1038/ja.2014.142

Table 3.

Fractional inhibitory concentration index (ΣFIC) range of thiazole compounds 1 and 2 in combination with teicoplanin and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus (MRSA and VISA).

Strain Vancomycin Teicoplanin
ΣFIC1
(+1)		 Result ΣFIC
(+2)		 Result ΣFIC
(+1)		 Result ΣFIC
(+2)		 Result
MRSA NRS107 0.50–0.56 S/I 0.31–0.50 S 0.53–1.00 I 0.53–0.53 I
MRSA NRS119 0.07–0.31 S 0.28–0.31 S 0.50–0.53 S/I 0.53–0.75 I
MRSA NRS123 0.19–0.50 S 0.19–0.31 S 0.53–1.00 I 0.53–1.00 I
MRSA NRS194 0.13–0.50 S 0.13–0.56 S/I 0.28–1.00 S/I 0.28–1.00 S/I
MRSA NRS384 0.16–0.50 S 0.13–0.31 S 0.53–1.00 I 0.53–0.75 I
MRSA NRS385 0.13–0.50 S 0.13–0.31 S 0.53–1.00 I 0.53–1.00 I
MRSA ATCC 43300 0.09–0.50 S 0.09–0.31 S 0.50–0.52 I 0.50–0.56 S/I
VISA NRS1 0.26–0.56 S/I 0.63 I 0.16–1.00 S/I 0.19–2.00 S/I
VISA NRS19 0.53–0.56 I 0.50 S 0.53–1.03 I 0.53–1.03 I
VISA NRS37 0.53–0.56 I 0.75 I 0.09–1.01 S/I 0.13–2.00 S/I
1

Results for the FIC index are as follows: ≤ 0.5, synergistic (S); >0.5 to ≤4.0, indifference (I); >4, antagonistic (A). Results are reported from two independent experiments.