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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Antibiot (Tokyo). 2014 Oct 15;68(4):259–266. doi: 10.1038/ja.2014.142

Table 4.

Re-sensitization of vancomycin-resistant Staphylococcus aureus (VRSA) to vancomycin and teicoplanin using a subinhibitory concentration (½ × MIC) of compound 1 or 2.

Strain 1 + Teicoplanin 2 + Vancomycin 1 + Teicoplanin 2 + Teicoplanin
Re-
sensitization		 ΣFIC1 Re-
sensitization		 ΣFIC Re-
sensitization		 ΣFIC Re-
sensitization		 ΣFIC
VRS1 <4-fold >1.50 <4-fold 1.00 0-fold >2.00 64-fold 0.63
VRS4 <4-fold 1.13 512-fold 0.50 0-fold 2.00 32-fold 0.50
VRS5 4-fold 1.25 512-fold 0.50 2-fold 1.50 32-fold 0.50
1

Results for the FIC index (ΣFIC) are as follows: ≤ 0.5, synergistic (S); >0.5 to ≤4.0, indifference (I); >4, antagonistic (A).