Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Overall symptoms of tinnitus
RCT	50 people with subjective tinnitus	Proportion of people with improvement in tinnitus (measured on a tinnitus score [scale of 0–10; increasing score is associated with increasing disturbance from tinnitus]) 3 months 87% with acamprosate 333 mg three times daily 44% with placebo Absolute numbers not reported	P = 0.0004 It is unclear whether the difference in scores reflects a clinically important improvement in tinnitus People who withdrew from the RCT were not included in the data analysis, which would have affected the results	Effect size not calculated	acamprosate