Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Tinnitus loudness
RCT Crossover design	26 people In review	Improvement in subjective tinnitus loudness (mean subjective rating on a scale of 1–7) 6 weeks 4.3 with trimipramine (150 mg/day for 6 weeks) 4.0 with placebo	Reported as not significant P value not reported		Not significant
RCT 4-armed trial	225 people In review	Proportion of people with improvement in subjective tinnitus loudness at rest 28% with amitriptyline (10 mg three times a day for 10 weeks) 5% with placebo Absolute numbers not reported	P <0.011 (as reported in RCT) The review reported that results were presented as percentages, and further analysis is not possible	Effect size not calculated	amitriptyline
Overall symptoms of tinnitus
RCT	37 people with no history of depression In review	Proportion of people with a decrease in subjective tinnitus 6 weeks 19/20 (95%) with amitriptyline (50 mg/night for 1 week followed by 100 mg/night for 5 weeks) 2/17 (12%) with placebo	Statistical analysis between groups not reported
RCT Crossover design	26 people In review	Proportion of people with worsening of tinnitus (mean subjective rating on a scale of 1–7) 6 weeks 7/19 (37%) with trimipramine (150 mg/day for 6 weeks) 4/19 (21%) with placebo	Significance not assessed
RCT	117 people; results are reported for the 92 people who completed the follow-up period In review	Proportion of people reporting overall improvement in tinnitus severity (measured by asking "Has your tinnitus improved?") 6 weeks with nortriptyline (titrated to maintain therapeutic blood levels for depression) with placebo Absolute numbers not reported	Reported as not significant P value not reported		Not significant