Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	40 people In review	Adverse effects with alprazolam (initially 0.5 mg/night) with placebo	The RCT used dose adjustment of alprazolam but no dose adjustment of placebo, potentially biasing the results because of a difference in the attention given to people in the 2 groups
RCT Crossover design	36 people	Proportion of people who withdrew from treatment 2 with alprazolam 0.5 mg three times daily (on escalating scale to minimise adverse effects) 4 with placebo	Significance not assessed