Table 2.
Pathological response in breast [n (%)] following NAC
| PATHOLOGICAL RESPONSE GRADE [n(%)] b * | ||||
|---|---|---|---|---|
| GROUPS (n = 107) a | 5(PCR) | 4(MRD) | 3(PR) | 2/1(PoR/NR) |
| A | 11 (30.6) | 10 (27.8) | 10 (27.8) | 5 (13.9) |
| (n = 36) | ||||
| B | 15 (40.5) | 10 (27) | 9 (24.3) | 3 (8.1) |
| (n = 37) | ||||
| C | 1 (5.6) | 1 (5.6) | 6 (27.8) | 10 (16.1) |
| (n = 18) | ||||
| D | 2 (12.5) | 2 (12.5) | 5 (31.3) | 7 (43.8) |
| (n = 16) | ||||
| (A + C) | 12 (22.2) | 11 (20.4) | 15 (27.8) | 16 (29.6) |
| (n = 54) | ||||
| (B + D) | 17 (32.1) | 12 (22.6) | 14 (26.4) | 10 (18.8) |
| (n = 53) | ||||
aTwo patients received preoperative radiotherapy and one had no demonstrable cancer in the breast (involved ALN on presentation).
bPCR : complete response, no residual invasive tumour cells in specimen, DCIS accepted (grade 5); MRD : minimal residual disease, >90% loss of tumour cells, (grade 4); PR : partial response, moderate reduction in tumour cell burden, between 30%-90% reduction in tumour cells (grade 3); PoR : poor response, minimal loss (<30%) of tumour cells, (grade 2); NR : no response/no change in overall cellularity, (grade 1).
*Pathological responses were not significantly different between the Groups (p>0.05); A + C versus (v) B + D: χ 2 = 3.717, p = 0.446 (Pearson Chi-Square Test).