Table 1.

The distribution of the MTHFR C677T genotypes for cases and controls

Author	Publication year	Country	Ethnicity	Case			Control			Pa
				CC	CT	TT	CC	CT	TT
Chedraui, P.[11]	2014	Ecuador	Caucasian	59	73	18	47	91	12	0
Coral-Vazquez, R. M.[56]	2013	Mexico	Latino	38	109	83	71	166	115	0.43
Lykke, J. A[60]	2012	Denmark	Caucasian	113	118	31	906	793	143	0.09
Dissanayake, V. H.[61]	2012	Sri Lanka	Asian	136	36	3	142	27	2	0.58
Klai, S.[45]	2011	Tunisia	Caucasian	22	20	2	61	39	0	0.02
Mislanova, C.[12]	2011	Austria	Caucasian	12	11	5	21	17	2	0.54
Aggarwal, S.[62]	2011	India	Asian	160	33	7	134	58	8	0.59
Sun [55]	2011	China	Asian	32	22	22	331	154	28	0.08
Stiefel, P.[63]	2009	Spain	Caucasian	157a	–	27	113	–	21	–
Shen, X.N[31]	2009	China	Asian	12	35	14	30	21	9	0.12
Wang, S.M[46]	2008	China	Asian	6	19	17	13	40	11	0.04
Zhang, X.Y[64]	2008	China	Asian	22	21	7	29	8	3	0.05
Muetze, S.[65]	2008	German	Caucasian	30	34	7	35	29	15	0.06
Canto, P.[18]	2008	Mexico	Latino	36	66	23	61	131	82	0.53
Stonek, F.[66]	2007	Austria	Caucasian	9	14	2	669	573	155	0.06
Nagy, B.[67]	2007	Hungary	Caucasian	71	68	25	32	35	5	0.27
Zhang, Z.H[54]	2007	China	Asian	12	21	20	10	30	9	0.12
Dusse, L. M.[68]	2007	Brazil	Latino	16	12	2	46	31	6	0.81
Jaaskelainen, E.[69]	2006	Finland	Caucasian	78	43	12	64	42	6	0.79
Demir, S. C.[70]	2006	German	Caucasian	19	29	8	43	47	12	0.88
Dalmaz, C. A.[19]	2006	Brazil	Latino	31	27	17	76	51	18	0.05
Mello, G.[71]	2005	Italy	Caucasian	729a	–	79	793	–	15	–
Driul, L.[72]	2005	Italy	Caucasian	34 a	–	5	57	–	7	–
Davalos, I. P.[20]	2005	Mexico	Latino	13	14	6	24	27	11	0.48
Also-Rallo, E.[26]	2005	Spain	Caucasian	78	59	20	63	75	19	0.64
Yilmaz, H.[73]	2004	Turkey	Caucasian	29	28	7	24	17	6	0.30
Williams, M. A[74]	2004	Peru	Latino	37	61	25	62	85	30	0.92
Perez-Mutul, J.[75]	2004	Mexico	Latino	33	66	49	36	80	61	0.30
Pegoraro, R. J.[36]	2004	South Africa	Asian	464	76	2	298	38	2	0.52
De Maat, M. P.[41]	2004	Netherlands	Caucasian	78	59	20	63	75	19	0.64
Fabbro, D.[76]	2003	Italy	Caucasian	44 a	–	8	68	–	12	–
Prasmusinto, D.[22]	2002	German	Caucasian	7	7	1	12	15	7	0.57
Prasmusinto, D.[22]	2002	Croatian	Caucasian	11	12	2	18	15	5	0.51
Prasmusinto, D.[22]	2002	Indonesian	Asian	34	6	1	22	5	0	0.60
Morrison, E. R.[29]	2002	Scotland	Caucasian	169	193	42	81	66	17	0.52
D’Elia, A. V.[77]	2002	Italy	Caucasian	52 a	–	6	65	–	9	–
Watanabe, H.[78]	2001	Japan	Asian	40	59	34	89	103	32	0.80
Raijmakers, M. T.[30]	2001	Scotland	Caucasian	72	74	21	205	162	36	0.62
Livingston, J. C.[37]	2001	USA	Caucasian	66	34	10	61	27	7	0.12
Lachmeijer, A. M.[13]	2001	Netherlands	Caucasian	66	94	14	58	51	11	0.96
Kim, Y. J.[31]	2001	USA	Caucasian	131	117	33	167	152	41	0.47
Kaiser, T.[54]	2001	Australia	Caucasian	71	66	19	37	31	11	0.29
Alfirevic, Z.[64]	2001	UK	Caucasian	56 a	–	7	42	–	2	–
Rigo, J., Jr.[33]	2000	Hungary	Caucasian	46	66	8	42	53	6	0.04
Rajkovic, A.[79]	2000	USA	Caucasian	142	28	1	151	32	0	0.19
Li, K.[80]	2000	China	Asian	9	30	18	5	16	3	0.09
Laivuori, H.[81]	2000	Finland	Caucasian	64	45	4	56	40	7	0.97
Kupferminc, M. J.[82]	2000	Israel	Caucasian	48 a	–	15	114	–	12	–
Kobashi, G.[23]	2000	Japan	Asian	25	40	8	83	99	33	0.7
Kaiser, T.[83]	2000	Australia	Caucasian	65	68	14	46	49	14	0.87
Powers, R. W.[84]	1999	USA	Caucasian	35	49	15	54	46	14	0.39
O’Shaughnessy, K. M.[35]	1999	UK	Caucasian	138	114	31	51	37	12	0.2
Kupferminc, M. J.[23]	1999	Israel	Caucasian	27 a	–	7	101	–	9	–
Chikosi, A. B.[85]	1999	South Africa.	Asian	86	18	1	97	13	0	0.51
Sohda, S.[5]	1997	Japan	Asian	19	32	16	38	49	11	0.42
Grandone, E.[6]	1997	Italy	Caucasian	66 a	–	28	105	–	24	–

^aCC+CT