Table 1.
Parameters | Symbol | Value | Source | |
---|---|---|---|---|
Baseline model parameters | ||||
Mosquito density (ratio female mosquitoes/humans) | m | 75 | Assumed value within published range | |
Human feeding rate, bites per mosquito per day | a | 0.035 - 0.32 | Monthly estimations from fitting cohort data; values within published range | |
Mean: 0.088 | ||||
Susceptibility of an individual to infection after being bitten by an infectious mosquito | b | 0.05 | Estimation using cohort and published data | |
Mosquito susceptibility to infection after biting an infectious individual | c | 0.41 | Published data | |
Duration of human latent period for Pf* in d]’ cays (l = l 1 + l 2 ) | l | 21 | Published data | |
Duration from sporozoite inoculation to development of blood asexual parasites in days | l 1 | 11 | Published data | |
Duration from asexual blood stage infection to development of gametocytes in days | l 2 | 10 | Published data | |
Duration of mosquito latent period in days | n | 11 | Published data | |
Daily human mortality rate | h | 0.00005 | Published data | |
Daily mosquito mortality rate | g | 0.16 | Published data | |
Fraction of symptomatic infections | y | 0.65 | Cohort data | |
Treatment effectiveness | ε | 0.98 | Published data | |
Duration of infectious period in treated humans with ACT (in days) | r 1 | 14 | Published data | |
Duration of infectious period in untreated humans in days (r 2 = r 2a + r 2b ) | r 2 | 200 | Published data | |
Duration of presence of blood asexual parasites in untreated humans in days | r 2a | 80 | Published data | |
Duration of infectious period in untreated humans after clearance of blood asexual parasites in days | r 2b | 120 | Published data | |
FSAT parameters | ||||
Coverage of FSAT | Δ | 1 | Assumption | |
Duration of FSAT in days | v | 1 | Assumption | |
Sensitivity of microscopy for detecting Pf* asexual stages | s 1a | 0.5 | Published data | |
Sensitivity of microscopy for detecting Pf*gametocytes | s 1g | 0.1 | Published data | |
Sensitivity of highly sensitive diagnostic tests for detecting asexual stages | s 2a | 0.95 | Assumption | |
Sensitivity of highly sensitive diagnostic tests for detecting gametocytes | s 2g | 0.8 | Assumption |
*Pf = P. falciparum.