Table 3.
Stability of LUME and 97–63 in rat plasma
| LUME | 97-63 | |||||||
|---|---|---|---|---|---|---|---|---|
| Mean a | SD | Precision b (%) | Accuracy c (%) | Mean a | SD | Precision b (%) | Accuracy c (%) | |
| 10 (ng/mL) | ||||||||
| 0 hr (for all) | 9.6 | 0.22 | 2.24 | 96.20 | 10.2 | 0.46 | 4.54 | 109.12 |
| 24 hrs (AS) | 9.9 | 0.40 | 4.05 | 103.72 | 4.3 | 0.16 | 3.74 | 104.67 |
| 6 hrs (BT) | 9.8 | 0.69 | 7.01 | 101.73 | 3.8 | 0.16 | 4.30 | 93.85 |
| FT-3 | 9.6 | 0.74 | 7.74 | 99.48 | 3.9 | 0.13 | 3.34 | 98.16 |
| 15 days at −70°C | 9.6 | 0.24 | 2.49 | 105.73 | 4.1 | 0.12 | 2.92 | 100.47 |
| 400 (ng/mL) | ||||||||
| 0 hr (for all) | 387.3 | 16.61 | 4.29 | 96.83 | 405.2 | 14.16 | 3.50 | 101.29 |
| 24 hrs (AS) | 393.2 | 17.62 | 4.48 | 101.51 | 407.0 | 16.16 | 3.97 | 100.45 |
| 6 hrs (BT) | 391.3 | 19.01 | 4.86 | 101.03 | 388.3 | 14.47 | 3.73 | 95.85 |
| FT-3 | 413.5 | 12.34 | 2.98 | 106.78 | 404.3 | 6.15 | 1.52 | 99.79 |
| 15 days at −70°C | 397.2 | 9.28 | 2.34 | 102.54 | 400.0 | 8.34 | 2.09 | 98.72 |
a Back calculated plasma concentrations (n = 6).
b Expressed as % RSD = (SD/mean) × 100.
c Calculated as (mean determined concentration/nominal concentration) × 100.