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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Biomaterials. 2015 Apr 28;57:142–152. doi: 10.1016/j.biomaterials.2015.04.015

Fig. 2. Viscosity traces of candidate polymer compositions.

Fig. 2

The maximum viscosity target of 150 centipoise (cP) was specified to permit a formulation to be injectable through a commercially available 2.8F microcatheter. Viscosities were measured between 18 and 37°C, representing the injecting temperature range. A) 16% w/w formulations of reconstituted lyophilized polymer non-sheared (NS) of both SELP-47K (47K) and SELP-815K (815K) remained below 150cP. B) 14% w/w sheared SELP-815K began to gel upon thawing the sample and the viscosity was above the specification. Reduction to 12% w/w sheared SELP-815K provided appropriate viscosity. C) Comparison of non-sheared and sheared 12% w/w SELP-815K. 12% sheared (S) SELP-815K showed increasing viscosity as a result of network formation but the viscosity remained in the injectable range. D) Comparison of 12% w/w sheared SELP-815K and SELP-47K. The lack of increasing viscosity with increasing temperature by 12% w/w sheared SELP-47K indicated slower network formation. For all traces n=3 ± SEM.