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. 2015 May 8;15:374. doi: 10.1186/s12885-015-1363-1

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© Pignochino et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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In vivo antitumor effect in human MPM xenograft models. (A) After tumor establishment, 6 mice per group were randomized to daily receive sorafenib 5 mg/kg/day, everolimus 1 mg/kg/day, their combination or vehicle alone. Tumor volume was monitored as described in the “material and methods” section and is reported in graph as mean ± St. Dev (Y error bar). *, p < 0.05 vs vehicle alone; †, p < 0.05 vs either single agent and vehicle alone. (B) Vascular specific CD31 staining and (C) TUNEL assay on vehicle (NT), everolimus 1 mg/kg/day (EV), sorafenib 5 mg/kg/day (SOR), and combination (CB) treated xenografts.