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. 2015 May 13;5:10181. doi: 10.1038/srep10181

Figure 2. Iron overload selectively affected the frequencies of immature hematopoietic cells.

Figure 2

Mice were injected with 25 mg/ml iron dextran in the iron overload group or were injected with normal saline in the control group. (a) The number of BMMNCs is presentedas the means ± SE of three independent experiments. (b–c) The frequencies of erythroid and myeloid cells are presented as the means ± SE of three independent experiments. (d–f) The frequencies of hematopoietic progenitor cells (HPCs) (Lin-c-kit+Sca–1–, LKS–), hematopoietic stem cells (HSCs) (Lin–c-kit+Sca–1+, LKS+) and long–term hematopoietic stem cells (LT-HSCs) (CD34–LKS+) in BMMNCs are presented as the means ± SE of three independent experiments. N = 5 mice/ group. ***P < 0.001 vs. CTL; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. IO.