Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 17;4(4):231–242. doi: 10.1002/psp4.28

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Two-strain model accounting for drug-sensitive (wildtype) and drug-resistant virus. I_wt, I_res are the two populations of hepatocytes infected with wildtype virus V_wt and drug-resistant virus V_res, respectively. The model assumes that V_res is generated from V_wt, with rate μ but no backward mutation. Mutant strain is produced with a lower production rate p_res compared to wildtype virus (p_wt) due to its lower relative fitness (f_i = p_res/p_wt). Each viral strain has different sensitivity to treatment, ε_wt and ε_res. The model predicts that resistant virus should already exist before treatment at frequency μ/(1 − p_res/p_wt).