Table 2.
Parameters for case study 1
| Compound | MEC (µM) | Vss (L/kg) | CL (heps) (L/h/kg) | CL (LBF) (L/h/kg) | t1/2 (h) |
|---|---|---|---|---|---|
| 1A | 0.26 (0.13–0.52) | 1.5 (0.50–4.5) | 0.43 (0.14–1.3) | 0.20 (0.067–0.60) | 3.3 |
| 1B | 0.40 (0.20–0.80) | 1.3 (0.42–3.8) | 0.31 (0.10–0.93) | 0.12 (0.040–0.36) | 4.1 |
| 1C | 0.079 (0.040–0.16) | 0.82 (0.27–2.5) | 0.23 (0.077–0.69) | 0.14 (0.047–0.42) | 3.1 |
| 1D | 0.073 (0.037–0.14) | 0.55 (0.18–1.7) | 0.12 (0.040–0.36) | 0.13 (0.043–0.39) | 3.0 |
| 1E | 0.056 (0.028–0.12) | 0.47 (0.16–1.4) | 0.09 (0.030–0.27) | 0.14 (0.047–0.42) | 2.8 |
CL, clearance; LBF, liver blood flow; MEC, minimum effective concentration; Vss, volume of distribution at steady state; heps, hepatocytes.
Point estimates and 95% uncertainty ranges. The parameter t1/2 is derived from CL and Vss.