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. 2015 May 13;9:120. doi: 10.3389/fnbeh.2015.00120

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Copyright © 2015 Hoffmann, Zimmermann and Spengler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plastic DNA methylation mediates switches in circadian cycles. Altered lightning environment (22-h instead of 24-h days) induces enduring changes in the genetically determined period of circadian behavior in adult mice. Circadian and non-circadian genes downstream to the core TF Bmal and Clock undergo dynamic changes in DNA methylation (black lollipops) and histone modifications (red and green triangles) leading to altered transcriptional output and changes in mouse behavior.