Table 2.
Structural comparison of the DFG-in states of selected kinases harboring an ADFG sequence.
| PDB ID |
Overall identity / similarity (%)a |
Kinase | r.m.s.d. (Å)b |
|---|---|---|---|
| 2HK5 | 22.3 / 41.1 | HCK | 0.2 |
| 2DQ7 | 23.8 / 40.9 | Fyn | 0.2 |
| 1QPC | 23.7 / 39.0 | LCK | 0.2 |
| 2ZV7 | 23.8 / 40.2 | Lyn | 0.2 |
| 3KF4 | 24.8 / 42.6 | ABL1 | 0.3 |
| 2EU9 | 19.9 / 36.5 | CLK3 | 0.3 |
| 3COK | 35.1 / 56.2 | PLK4 | 0.3 |
| 2XIK | 30.3 / 49.0 | STK25 | 0.3 |
| 2J7T | 28.3 / 46.9 | STK10 | 0.3 |
| 3A7F | 28.6 / 48.1 | STK24 | 0.3 |
| 3COM | 26.8 / 49.7 | STK4 | 0.3 |
| 2QLU | 21.7 / 41.5 | ACTR-IIB | 0.3 |
| 2J51 | 28.5 / 49.3 | hSLK | 0.3 |
| 3S95 | 22.8 / 39.9 | LIMK1 | 0.3 |
| 3LXL | 24.6 / 42.4 | JAK3 | 0.3 |
| 2BDJ | 22.9 / 40.5 | Src | 0.3 |
| 1XJD | 30.8 / 49.3 | PKC theta | 0.4 |
| 2VD5 | 30.8 / 48.4 | DMPK | 0.4 |
| 2ETR | 30.2 / 48.2 | ROCK 1 | 0.5 |
| 2VZ6 | 31.3 / 48.1 | CaMK2A | 0.5 |
| 3DAK | 25.9 / 41.3 | OSR1 | 1.0 |
| 3PXR | 26.4 / 44.4 | CDK2 | 1.0 |
| 3FE3 | 31.2 / 51.5 | MAPK3 | 1.0 |
| 3LMG | 20.8 / 39.1 | erbB-3 | 1.0 |
| 3KY2 | 25.4 / 42.2 | FGFR1 | 1.1 |
| 3L8P | 25.2 / 40.2 | Tie-2 | 1.2 |
| 3PLS | 21.3 / 35.4 | RON | 1.2 |
| 3BRB | 22.9 / 36.7 | MER | 1.3 |
| 1BLX | 24.3 / 41.0 | CDK6 | 1.3 |
| 3F66 | 21.1 / 36.0 | c-Met | 1.4 |
a
Computed with EMBOSS Needle (http://www.ebi.ac.uk/Tools/psa/emboss_needle/) against the kinase domain of human Aurora A.
b
r.m.s.d. = root mean square deviation of the main chain atoms upon superposition with the ADFG of Aurora A in complex with 1 (computed with Superpose from the CCP4 program suite).