. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: Nat Neurosci. 2014 Nov 24;18(1):17–24. doi: 10.1038/nn.3886

Table 1.

Candidate transcriptions factors for lineage conversion to nociceptor neurons. Lit, literature; Exp, transcriptome of sorted nociceptors compared to proprioceptors; BioGPS²⁷.

Gene	Source	Family	Role in Reprogramming/ Sensory System
Ascl1	Lit	Basic helix-loop-helix / achaete-scute	Neuronal lineage reprogramming⁴
Drgx (Drg11)	Lit	Helix-turn-helix / Paired box	Survival of peptidergic and non-peptidergic nociceptors⁴⁸
Ebf1	Exp	Zinc-finger	Downstream of Ngn⁴⁹
Etv1	Exp	Helix-turn-helix/tryptophan clusters	Proprioceptive marker²⁴
Isl2	Exp, BioGPS	Homeo-domain / LIM region	Unknown
Klf7	Lit, Exp, BioGPS	Zinc-finger / Krueppel like	TrkA maintenance²⁵
Myt1L	Lit	Zinc-finger	Neuronal lineage reprogramming⁴
Ngn1	Lit	Basic helix-loop-helix	TrkA and subsequent TrpV1 expression²¹
Pknox2	Exp	Homeo-domain / TALE	Unknown
Pou4f1 (Brn3a)	Lit	Homeo-domain / POU (Class IV)	Neuronal lineage reprogramming⁴
Runx1	Lit	β-scaffold / Runt	Non-peptidergic identify and TrpV1 expression²³
Tlx3	Lit	Helix-turn-helix / homeo-domain	Glutamatergic identity⁵⁰