Skip to main content
. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: J Med Chem. 2012 Aug 30;55(17):7392–7416. doi: 10.1021/jm300334d

Table 2.

Structure activity relationship studies and in vitro inhibitory activities of library 6 against Aurora A.

graphic file with name nihms-685815-f0012.jpg
Entry Compound R1 R2 R3 R4 R5 IC50 (nM)a
24 6a H H ortho-F para-CO2H H 3.7 ± 0.7 nM
25 6b H H ortho-CF3 All H H 1773 ± 142 nM
26 6c H H 2-Cl-4-F para-CO2H H 2.0 ± 0.2 nM
27 6d H H ortho-OCF3 para-CO2H H 28 ± 4.8 nM
28 6e H H ortho-OMe para-CO2H H 4.0 ± 0.2 nM
29 6f H H ortho-OMe All H H 46.6 ± 8.4 nM
30 6g H H ortho-CN All H H 560 ± 70.3 nM
31 6h H H ortho-CF3 para-CO2H H 35.1 ± 4.0 nM
32 6i H H ortho-Br para-CO2H H 2.1 ± 0.4 nM
33 6j H H ortho-Cl para-CH2-CO2H H 3.3 ± 1.5 nM
34 6k H H ortho-Cl para-CO2H, meta-OH H 6.6 ± 0.6 nM
35 61 H H ortho-F All H H 284 ± 11.3 nM
36 6m H H ortho-I para-CO2H H 35 ± 3.3 nM
37 6n H H ortho-CN para-CO2H H 43 ± 8 nM
38 6o H H ortho-Cl meta-CO2H H 18.7 ± 1.5 nM
39 6p H H ortho-Cl para-CONH2 H 30.2 ± 1.4 nM
40 6q H H ortho-phenyl para-CO2H H 149 ± 23 nM
41 6r H H ortho-Cl para-CO2H CH3 8.5 ± 1.2 nM
42 6s H H ortho-Cl para-CO2H CH3-CH2 50.2 ± 2.7 nM
43 6t F H ortho-Cl meta-CO2H H 4.5 ± 1.1 nM
a

Determined in-house using the DiscoveRx format.