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Selectivity profile of compound 9m against a panel of kinases at 1 μM.
| % Inhibition at 1 μM | ||
|---|---|---|
| Kinase: | 9m | VX-680 |
| ABL2/ARG | 75 | 98 |
| AKT1 | 8 | 3 |
| Aurora A | 99 | 100 |
| Aurora B | 93 | 98 |
| Aurora C | 84 | 86 |
| CDK1/cyclin B | 90 | 5 |
| CDK2/cyclin A | 94 | 7 |
| CHK1 | 8 | 16 |
| CHK2 | 30 | 4 |
| FLT3 | 95 | 102 |
| JAK2 | 94 | 81 |
| NEK11 | 21 | 11 |
| NEK2 | 3 | −3 |
| NEK6 | 11 | −5 |
| PLK1 | 64 | 0 |
| RET | 70 | 96 |
| ROCK1 | −5 | −2 |
| TRKA | 39 | 95 |
| WEE1 | 16 | 2 |
