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. 2015 May 13;6:467. doi: 10.3389/fmicb.2015.00467

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Copyright © 2015 Fay and Panté.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Parvoviruses cause disruption of the NE for nuclear import. Electron micrographs of NE cross-sections from Xenopus oocytes mock-injected (A) or injected with the parvovirus MVM (B–E). Arrowheads point to NPCs. Brackets indicate breaks in the NE caused by MVM, which are often found close to NPCs (indicated by ^∗). Virions are found close to the breaks (B, indicated by ^∗∗), associated with the outer nuclear membrane (D, arrows), and in the perinuclear space (C, arrows). Small vesicles are found close to the breaks (E, arrow). Scale bars, 100 nm; n, nucleus; c, cytoplasm. Reproduced with permission from Cohen and Pante (2005).