Table 3.
Completed and ongoing clinical trials with CIK cells for hematological malignancies are listed.
| Pts. | Diagnosis | CIK cell preparation | Status | Clinical site | Reference(s)/NCI Identifier |
|---|---|---|---|---|---|
| 11 | AML, HL, CML, ALL, MDS | LK or PB; 1,000 U/ml IFN-γ + OKT3 + IL-2 for 20–26 d; median number of total allogeneic CIK cells 2.4 × 106/kg (7.2–87.4); phase I | Published | Italy | (157) |
| 5 | AL | UCB washout after UCB transplantation | Published | Italy | (162) |
| 9 | DLBCL | Autologous PB; 2,000 U/ml IFN-γ + OKT3 + IL-2 | Published | China | (163) |
| 10 | Lymphoma (n = 2) | 1,000 U/ml IFN-γ + OKT3 + IL-2; CIK cells then transfected with pCEP-IL-2-plasmid | Published | Germany | (164) |
| 1 | Plasmocytoma | Autologous CIK cells; monthly for 21 courses | Published | China | (165) |
| 12 | Lymphoma (n = 6) | LK or PB; median 28 × 109 (range, 6–61) CIK cells per patient | Published | Italy | (166) |
| 41 | MDS/MPD | Post-transplantation infusion of allogeneic CIK cells as consolidation therapy; phase II | Recruiting | Stanford University, USA | NCT01392989 |
| 17 | AML/MDS | Autologous CIK cells after HSCT or in patients unfit for standard curative chemotherapy; phase I/II | Completed | Singapore General Hospital | NCT00394381 |
| 11 | CML | Adoptive immunotherapy in patients receiving standard drug therapy; phase II | Completed | Singapore General Hospital | NCT00815321 |
| 20 | Hematological malignancies | Allogeneic CIK cells as post-HSCT immunotherapy; phase I | Active, not recruiting | NIH, US | NCT00185757 |
| 20 | Hematological malignancies | Allogeneic CIK cells for relapse after allogeneic HSCT; phase I/II | Recruiting | Singapore General Hospital | NCT00460694 |
PBMC, peripheral blood mononuclear cells; AL, acute leukemia; DLBCL, diffuse large B-cell lymphoma; LK, leukapheresis; CML, chronic myeloid leukemia; MDS, Myelodysplastic syndromes; MPD, myeloproliferative disorders; d, day; UCB, umbilical cord blood; SCGM, stem cell growth medium; MM, multiple myeloma. www.clinicaltrials.gov website last accessed March 2015.