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. 2015 Mar 11;2:7. doi: 10.3389/fmolb.2015.00007

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Copyright © 2015 Gielbert, Thorne and Hope.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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N-TAAPs from ovine TSEs. Graphs show calculated concentrations (±SD) of N-TAAP peptides determined by chip-HPLC SRM mass spectrometry of digest preparations from the brain stem of individual animals. (A,B) Classical scrapie: VRQ/VRQ Swaledale, neutered male, homebred; (C,D) Experimental CH1641 scrapie: AHQ/AHQ Cheviot, neutered male; (E,F) Experimental BSE: ARQ/ARQ Romney. (A,C,E) without proteinase K treatment; (B,D,F) with proteinase K treatment. Asterisks are used to point out the peptides with pyroglutamyl N-termini.