Fig. 5.

Aggregate estrogen metabolism profiles for OSE cells and cancer cell lines expressed as the net conversion of substrate to product (black columns). (A) EST and 17BHSD reductase, (B) 17BHSD reductase, (C) STS, (D) STS and 17BHSD reductase. Bars indicate mean ± SEM. (A) and (B) n = 3 (OSE, SKOV3 and PEO1); (C) and (D) n = 10 (OSE), n = 3 (SKOV3 and PEO1). Statistical analysis was by one-way ANOVA followed by Tukey’s post-hoc tests. (A) P < 0.001, F = 13,800, df = 2, 6. *P < 0.05, ***P < 0.001. Statistical analysis was not performed in B–D due to undetectable activity in OSE cells.