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. 2015 May 14;3:27. doi: 10.1186/s40478-015-0205-3

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© Netzahualcoyotzi and Tapia; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Progressive alterations of the rear limbs induced by AMPA and protection by energy substrates. Representative posterior views of the rear limbs (C, contralateral; I, ipsilateral) and hind paw footprints (red, ipsilateral; black, contralateral) at the initial (day 1), the middle (day 4) and last day (day 7) of treatment. The AMPA-induced progressive alterations were prevented by pyruvate and βHB but not by ascorbate and GEE alone (not shown) or in combination (antioxidant mixture).