Table 4.
Androgen effects on tumor growth (induced by chemical carcinogens)
| Reference | Animal model | Type of androgen | Dose a | Tumor growth |
|---|---|---|---|---|
| 7,12-Dimethylbenz(a)anthracene (using androgens) | ||||
| Young and colleagues [60] | SD ratsb | T | 1.2 to 6?mg weekly | ? |
| DHT | 1.2 to 6?mg weekly | |||
| Heise and Gorlich [61] | SD rats | TP | 6 to 180?mg/kg weekly | ? (low dose only) |
| Teller and colleagues [62] | SD rats | MDTP and TP | Total of 480?mg for 8?weeks | ? |
| Shimkin and colleagues [16] | SD/Wistar rats | DP | 200?mg weekly for 6?weeks | No effect |
| Teller and colleagues [63] | SD rats | MDTP and TP | 3.75 to 60?mg weekly for 8?weeks | ? |
| Teller and colleagues [64] | SD rats | MDTP | 60?mg weekly for 8?weeks | ? |
| Mobbs [67] | SD rats | TP | 10 or 50?mg/kg weekly or a single 60?mg pellet | ? (high dose only) |
| Griswold and Green [68] | SD rats | MDTP and TP | 10?mg/kg daily for 20?days | ? |
| Briziarelli and colleagues [69] | SD rats | FBTA | 2 or 4?mg daily for 30?days | ? |
| Takahashi and colleagues [70] | SD rats | MDTP and TP | 6?mg weekly | ? |
| Quadri and colleagues [71] | SD rats | DmP | 0.5?mg daily for 3?weeks | ? |
| Horn and colleagues [72] | Inbred rats | Calsterone | 10?mg daily for 2 to 3?weeks | ? |
| Costlow and colleagues [73] | SD rats | TP | 8?mg weekly | ? |
| Zava and McGuire [74] | SD rats | TP | 2.4?mg weekly | ? |
| Teller and colleagues [65] | SD rats | MDTP | 200?mg/kg weekly for 5?weeks | ? |
| Teller and colleagues [66] | SD rats | MDTP | 3 to 100?mg/kg weekly for 4?weeks | ? (dose dependent) |
| Dauvois and colleagues [51] | SD rats | DHT | 3?cm silastic implant (30/100, DHT/cholesterol, w/w) | ? |
| Boccuzzi and colleagues [75] | SD rats | DHEA | 4?mg daily for 21?days | ? |
| Boccuzzi and colleagues [76] | SD rats | DHT | 25??g DHT daily for 20?days | ? |
| Gatto and colleagues [77] | SD rats | DHEA | 4?mg daily for 20?days | ? |
| Methylcholanthrene (using androgens) | ||||
| Ercoli and Briziarelli [79] | SD rats | DHT or DHT enol ethers | 2?mg daily for 30?days | ? |
| Shimkin and colleagues [16] | SD/Wistar rats | DP | 200?mg/kg weekly for 6?weeks | No effect |
| 7,12-Dimethylbenz(a)anthracene (using anti-androgens) | ||||
| Spinola and colleagues [78] | SD rats | Flutamide | 10?mg daily for 20?days | ? |
| Boccuzzi and colleagues [76] | SD rats | Flutamide | 2?mg daily for 20?days | ? |
DHEA, dehydroepiandrosterone; DHT, dihydrotestosterone; DmP, dromostanolone propionate; DP, drostanolone propionate; FBTA, 9?-fluoro-11?-hydroxybenzo[d,e] testosterone 17-acetate; MDTP, 2?-methyl-DHT propionate; SD, Sprague?Dawley; T, testosterone; TP, testosterone propionate. aSome doses are shown as weekly doses calculated based on the dosing regime in the original article. bFemale rats unless otherwise specified.