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Effect of pharmacological inhibitors PK11195, finasteride, and flumazenil alone on behavioral seizure stage (A and B) and electrographic AD duration (C and D) in fully kindled WT and DKO mice. Test inhibitors PK11195 (15 mg/kg), finasteride (50 mg/kg), and flumazenil (10 mg/kg) were administered intraperitoneally without midazolam 30 or 60 minutes prior to stimulation. Each point represents the mean ± S.E.M. of data from six to nine animals.
