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Sequence alignment of the second transmembrane domain among select Cys-loop receptor subunits. The residues are labeled according to Miller notation (Miller, 1989). Chemical structure of guanidine compounds amiloride and GMQ. Model of amiloride interacting with the intersubunit site of ethanol sensitive GLIC (Sauguet et al., 2013). Compound docked utilizing PatchDock online server.
