TABLE 1.

Amiloride increases the affinity of the wild-type human GABA-A ρ1 receptor for GABA

Summary of EC₅₀ and Hill coefficient values for GABA and coapplication of increasing concentrations of GABA and amiloride (30, 100, and 300 µM) on the wild-type human GABA-A ρ1 receptor. n ≥ 4 cells.

Compound	EC50	nH
	μM
GABA	9.4 ± 0.1	1.1 ± 0.2
+ 30 μM amiloride	7.8 ± 0.5*	1.0 ± 0.1
+ 100 μM amiloride	6.4 ± 0.6**	1.4 ± 0.2
+ 300 μM amiloride	5.9 ± 0.9**	0.9 ± 0.1
+ 10 μM GMQ	7.2 ± 0.6**	1.9 ± 0.3
+ 100 μM GMQ	4.8 ± 0.9**	2.6 ± 0.7

n_H, Hill coefficient.

^*P < 0.05; **P < 0.01.