TABLE 1.

[³H]DA uptake inhibition by select SRI compounds: one-component versus two-component fits

Dose-response curves (eight points) reported in Fig. 2 were fit to one- and two-component equations for the best-fit estimates of the IC₅₀ and E_max values (± S.D.).

Drug	One-Site IC50	One-Site Emax	Two-Site IC50-1	Two-Site Emax1	Two-Site IC50-2	Two-Site Emax2	Sum-of-Squares One-Site Fit	Sum-of-Squares Two-Site Fit	F Test
	nM	%I	nM	%I	nM	%I
SRI-29986	18 ± 4	75 ± 3	18 × 105 ± 1.7 × 105	37 × 108 ± 2.7 × 108	18 × 105 ± 1 × 105	37 × 108 ± 0.7 × 108	175	175	0
SRI-31335	156 ± 12	100 ± 1.5	99 ± 63	76 ± 54	564 ± 1177	27 ± 53	28.9	19.0	1.56
SRI-30835	15 ± 7	75 ± 5	6 ± 0.9	57 ± 2	4000 ± 1330	42 ± 4	677	14.2	140*

^*P < 0.001 vs. one-component fit (F test).