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. 2015 Jun;43(6):908–915. doi: 10.1124/dmd.114.061804

Fig. 2.

Fig. 2.

Proteomic correlation profiling revealed that aldehyde oxidase (AO/ADO) is an enzyme present in cytosolic fractions containing the hydrolytic enzyme activity involved in the metabolism of GDC-0834. (A) Table of top 15 most abundant proteins (UniProt) identified in fractions 24–31 based on total peptide spectral matches (PSMs); AO/ADO is shown in red. The hydrolytic enzyme activity (GDC-0834→M1) is shown in blue. Pearson correlations of each protein relative to GDC-0834→M1 metabolic activity are reported. Adjusted P values were corrected for multiple hypothesis testing using the q-value FDR-based approach. (B) Proteins ranked by Pearson correlation. The red diamond highlights AO/ADO.