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Homology model for aldehyde oxidase (AO) using the human sequence and the mouse crystal structure (PDB ID 3ZYV). (A) Induced-fit docking was used to dock GDC-0834 into the active site of AO near the MoCo group in an orientation that would suggest nucleophilic attack by the hydroxyl on the carbonyl of the amide bond. (B) Putative interactions of GDC-0834 within the active site of AO.
